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. 2012 Jun 27;32(26):8930–8939. doi: 10.1523/JNEUROSCI.1398-12.2012

Figure 3.

Figure 3.

Hypoxia and subsequent environmental enrichment increase the number of neurons arising from GFAP+ cells in an additive way. A, Schematic of the time course of hypoxia and enrichment experiment. B–I, Representative images showing the increase in reporter+/DCX+ neurons in hypoxic, enriched mice (F–I) as compared to hypoxic, standard reared mice (B–E) at P35; stereological quantification of the reporter+/DCX+ and reporter+/NeuN+ cell numbers is shown in N and O, respectively. J–M, Long-term increase in mature reporter+/NeuN+ neurons in response to hypoxia and enrichment at P90, with stereological quantification of reporter+/NeuN+ cell numbers at P90 shown in P. Q, The total number of eGFP+ cells at P35 increases in hypoxic and enriched mice. R, Proportion of reporter+ cells that attain neuronal (NeuN+), astroglial (GFAP+) and oligodendroglial (Olig2) fate are shown across groups. * denote significant increases from NSE; # denotes significant difference from all other groups.