Figure 6.

Environmental enrichment increases stem cell proliferation and survival. GCE;R26R and GCE;eGFP normoxic-reared mice were tamoxifen injected from P12–14, subsequently injected with CldU from P15–16 (to examine cell survival) (see schematic outline in Fig. 4A), reared in enriched or standard environment from P21–P35, and then injected with IdU 1 h before sacrifice (to examine cell proliferation) at P35. Both Sox2+ cell proliferation (A–C) and Sox2+ cell survival (D–F) were significantly increased in enriched mice. * denote significant increases from NSE.