Figure 8.

Schematic representation depicting hypoxia- and enrichment-induced changes in astroglial lineage. There is an increase in the number of neuronal cells in hypoxic-reared as well as normoxic enriched mice, shown in purple (DCX+) and blue (NeuN+). HEn mice show the greatest increase in total number of reporter+ neurons, suggesting an additive effect of hypoxia and enrichment on neurogenesis arising from GFAP+ cells. HSE mice show a greater proportion of the stem cell pool that is committed to the neuronal lineage (Sox2+DCX+, shown in red); this effect remains apparent in hypoxic mice that were subsequently enriched. In NEn mice there is no change in fate potential of NSC but rather a robust increase in the total stem/progenitor cell pool (shown in green, yellow, red) that is still present in Hen mice.