Table 1.
Mouse Transgenic WNT Reporters
| Driving the expression of a LacZ reporter | ||
| TOPGal | Three LEF/TCF consensus binding sites based on the pTOPFLASH reporter (Molenaar et al., 1996) with a c-fos minimal promoter | (DasGupta and Fuchs, 1999) |
| Axin2LacZ | A knock-in of the LacZ gene with a nuclear localization signal in the Axin2 gene locus | (Lustig et al., 2002) |
| BAT-gal | Seven TCF/LEF binding sites upstream of a 0.13-kb fragment containing the TATA box of siamois | (Maretto et al., 2003) |
| TCF/LEF-lacZ | Six TCF/LEF response elements with an hsp68 minimal promoter | (Mohamed et al., 2004) |
| BATlacZ | A TCF/LEF binding sequence upstream of a 0.13 kb Xenopus siamois minimal promoter; nuclear LacZ | (Nakaya et al., 2005) |
| ins-TOPGAL | Six LEF/TCF consensus binding sites and a minimal thymidine kinase promoter derived from pTOPFLASH; nuclear LacZ | (Moriyama et al., 2007) |
| Driving the expression of an EGFP reporter | ||
| Ax2/d2EGFP | A 5.6-kb DNA fragment including the Axin2 promoter, exon 1, and intron 1 sequences that contain several TCF/LEF binding sites; d2EGFP | (Jho et al., 2002) |
| ins-TOPEGFP | Six LEF/TCF consensus binding sites and a minimal thymidine kinase promoter derived from pTOPFLASH | (Moriyama et al., 2007) |
| LEF-EGFP | Seven multimerized LEF-1 binding sites with a c-fos minimal promoter | (current report) |