Skip to main content
. Author manuscript; available in PMC: 2012 Jul 18.
Published in final edited form as: Eur Respir J. 2011 Feb 24;38(1):15–28. doi: 10.1183/09031936.00029210

Table III.

Effect of Potential Confounding Factors on Associations of GSTM1, GSTT1 and GSTT2 Gene Expression Levels in Small Airway Epithelium and Alveolar Macrophageswith Regional Copy Number Variations1

p value2
Genetic
ancestry		 Smoking
status		 Pack
yr		 Gender Age
GSTM1
    SAE3 0.48 0.61 0.73 0.99 0.65
    AM 0.61 0.61 0.034 0.50 0.89
GSTT1
SAE 0.26 0.68 0.23 0.46 0.25
    AM 0.53 0.75 0.88 0.39 0.28
  GSTT2
    AM 0.10 0.34 0.19 0.99 0.90
1

Significance by p value of potential confounding variables on observed associations of CNV genotypewith GST isoenzyme gene expression is shown. GSTT2 was not significantly expressed in smallairway epithelium by Affymetrix “P-call”.

2

p values represent chi-squared tests except for pack-year and age, each of which was tested for interaction with CNV genotype by two factor ANOVA.

3

SAE, small airway epithelium; AM = alveolar macrophage.

4

Pack-yr was significantly higher among heterozygotes (haploid) for GSTM1 CNV than amonghomozygous nulls and wild types (diploid). There was a trend towards lower alveolar macrophageGSTM1 gene expression levels in smokers with greater than the median pack-yr smoking history, p=0.07.