Table 3.
Radiologic outcomes broken down by EBT, 3DRT, and IMRT groups with statistical comparison. EBT: endorectal brachytherapy; 3DRT: 3D conformal radiotherapy; IMRT: intensity-modulated radiotherapy; RT: radiotherapy; CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease; LN: lymph nodes.
| Radiologic outcome | EBT (n = 7) | 3DRT (n = 10) | IMRT (n = 7) | P |
|---|---|---|---|---|
| Post-RT tumor volume (median (range) cm3) | 1.0 (0.0–3.6) | 3.8 (0.7–26.3) | 0.4 (0.0–5.5) | 0.16∗ |
| Time between RT end and post-RT MRI (mean ± SD days) | 35 ± 3 | 35 ± 7 | 36 ± 9 | 0.98 |
| % decrease in tumor volume pre-RT → post-RT (median (range)) | 89 (38–100) | 87 (16–96) | 93 (66–100) | 0.78 |
| No. CR (%) | 1 (14) | 0 (0) | 1 (14) | 0.46 |
| No. PR (%) | 4 (57) | 9 (90) | 6 (86) | 0.23 |
| No. SD (%) | 2 (29) | 1 (10) | 0 (0) | 0.26 |
| No. PD (%) | 0 (0) | 0 (0) | 0 (0) | 1.0 |
| No. with clinically significant mesorectal LN before treatment (%) → no. after treatment (%) | 1 (14) → 0 (0) | 6 (43) → 3 (21) | 1 (14) → 1 (14) | — |
| No. with clinically significant pelvic LN before treatment (%) → no. after treatment (%) | 0 (0) → 0 (0) | 4 (29) → 4 (29) | 1 (14) → 0 (0) | — |
∗Medians and ranges are given to better represent the data, but statistical comparison was performed among means.