Table 1.
Observation | Marker for oxidative stress | Sampled region | Outcome (versus control) | References |
---|---|---|---|---|
In vivo | MDA | Blood, CSF | ↑ | [40] |
GSH reductase | Blood | ↑ | ||
Cu/Zn-SOD | Blood | ↑ | ||
Superoxide | Blood | ↑ | ||
| ||||
In vivo | HNE | Plasma, CSF | ↑ | [42] |
| ||||
In vivo | Lipoprotein oxidation | Plasma, CSF | ↑ | [43] |
Protein sulfhydryl groups | Plasma, CSF | ↓ | ||
α-Tocopherol | CSF | ↓ | ||
| ||||
In vivo | Cu/Zn/Mn-SOD activity | Skin fibroblasts | ↔ | [44] |
GPx activity | Skin fibroblasts | ↔ | ||
Catalase activity | Skin fibroblasts | ↔ | ||
| ||||
In vivo | Lipid oxidation products | Plasma | ↑ | [19] |
8-OHdG | Urine | ↑ | ||
| ||||
In vivo | Markers of oxidative stress | iPSCs | ↑ | [45] |
Sensitivity to oxidative stress | iPSCs | ↑ | ||
| ||||
In vivo | MDA | Blood | ↑ | [41] |
SOD activity | Blood | ↑ | ||
GPx | Blood | ↔ | ||
| ||||
Postmortem | Lipid peroxidation | SN | ↑ | [38] |
Reduced GSH | SN | ↓ | ||
Total iron | SN | ↑ | ||
Ferritin | SN | ↓ | ||
GPx activity | SN | ↓ | ||
Catalase activity | SN | ↓ | ||
| ||||
Postmortem | Iron | SN | ↑ | [39] |
MAO-B | SN | ↑ | ||
Cu/Zn-SOD | SN | ↑ | ||
Heme oxygenase | SN | ↑ | ||
GSH | SN | ↓ | ||
Vitamin C | SN | ↓ | ||
| ||||
Postmortem | GPx 4 | SN | ↑ | [46] |
| ||||
Postmortem | Protein oxidation | Caudate nucleus | ↑ | [35] |
Lipid peroxidation | Frontal cortex | ↑ | ||
Protein nitration | Caudate nucleus, putamen, frontal cortex | ↔ | ||
Total GSH | Caudate nucleus, putamen, frontal cortex | ↑ | ||
Catalase | Caudate nucleus, putamen, frontal cortex | ↔ | ||
SOD | Caudate nucleus, putamen, frontal cortex | ↔ | ||
GSH reductase | Caudate nucleus, putamen, frontal cortex | ↔ | ||
GPx | Caudate nucleus, putamen | ↑ |
Abbreviations: 4-HNE: 4-hydroxynonenal, 8-OhdG: 8-hydroxydeoxyguanosine, CSF: cerebrospinal fluid, GPx: GSH peroxidase, GSH: glutathion, iPSCs: induced pluripotent stem cells, MDA: malondialdehyde, SN: substantia nigra, SOD: sodium dismutase, ↑: increased, ↓: decreased, ↔: not different.