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IGF-IR blockade reduces phosphorylation of HER2 in trastuzumab-resistant cells. SKBR3 cells with acquired resistance to trastuzumab were untreated or treated with 0.25 μg/mL alpha IR3 IGF-IR monoclonal antibody overnight. Total protein lysates were western blotted for phosphorylated and total HER2 and IGF-IR. Actin served as a loading control.
