Table 1.
Major receptors | Ligand | Virus | Immunoevasin | Mechanism | References |
---|---|---|---|---|---|
Activating | |||||
| |||||
MICA | HCMV | UL142 | Internal retention | [68, 69] | |
KSHV | K5 | Ubiquitination/sequestration | [70, 71] | ||
HSV | ? | ? | [72, 73] | ||
HHV-7 | U21 | ? | [74] | ||
| |||||
HCMV | UL16 | Internal retention | [23, 75–77] | ||
HCMV | miR-UL112 | Translational downregulation | [78] | ||
NKG2D | KSHV | K5 | Ubiquitination/sequestration | [70, 71] | |
MICB | KSHV | miRK12-7 | Translational downregulation | [79] | |
HSV | ? | ? | [72, 73] | ||
EBV | miR-BART2-5p | Translational downregulation | [79] | ||
HHV-7 | U21 | ? | [74] | ||
| |||||
HCMV | UL16 | Internal retention | [23, 75–77] | ||
ULBP1–4 | HSV | ? | ? | [72] | |
HHV-7 | U21 | Lysosomal degradation | [74] | ||
| |||||
NCRs | AICL | KSHV | K5 | [71] | |
| |||||
DNAM-1 | PVR | ? | ? | ||
CD112 | ? | ? | |||
| |||||
Inhibitory | |||||
| |||||
HCMV | UL18 | MHC-I homologue | [80, 81] | ||
HCMV | UL40 | Signal prolongation | [82–84] | ||
HCMV | US2, US3, US6, US11 | Retention/degradation | [64, 67] | ||
KSHV | K5, K3 | Endocytosis | [85–87] | ||
HSV | ICP47 | TAP interference | [88–90] | ||
LIR-1, KIRs, CD94/NKG2A | MHC-I | EBV | vIL-10 | IL-10 homolog | [91] |
EBV | BNLF2a | TAP interference | [92, 93] | ||
EBV | BILF1 | Endocytosis/degradation | [94] | ||
HHV-6 | U21 analogues | Lysosomal degradation | [95] | ||
HHV-7 | U21 | Lysosomal degradation | [96–98] | ||
VZV | ORF66 | Internal retention | [99, 100] |