Table S1.
The within-gene variance in exonic dN/dS explained by the principal components broken down to eleven exon features (upper half); or to six feature categories (lower half).
| Var. explained | Comp 1 | Comp 2 | Comp 9 | Comp 10 | Comp 3 | Comp 4 | Comp 5 | Comp 6 | Comp 7 | Comp 8 | Comp 11 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exon features | (Sub)total | |||||||||||
| 8.00 | 6.47 | 1.09 | 0.27 | 0.11 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | |
| ASE/CSE exon type | 0.913 | 0.4536 | 0.4589 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
| Weighted exon frequency (WEF) | 0.909 | 0.4536 | 0.4556 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
| Average exonic expression level | 0.423 | 0.2722 | 0.0196 | 0.1247 | 0.0014 | 0.0045 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0000 | 0.0000 |
| 5′ intron length | 0.101 | 0.0907 | 0.0000 | 0.0005 | 0.0001 | 0.0002 | 0.0009 | 0.0033 | 0.0016 | 0.0036 | 0.0003 | 0.0000 |
| 3′ intron length | 0.020 | 0.0065 | 0.0000 | 0.0032 | 0.0001 | 0.0000 | 0.0042 | 0.0016 | 0.0000 | 0.0039 | 0.0001 | 0.0000 |
| Exon length | 0.753 | 0.5962 | 0.0305 | 0.1172 | 0.0051 | 0.0033 | 0.0001 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0000 |
| G+C content | 0.055 | 0.0324 | 0.0011 | 0.0103 | 0.0022 | 0.0002 | 0.0043 | 0.0025 | 0.0009 | 0.0013 | 0.0002 | 0.0000 |
| Exon duplicability | 0.025 | 0.0000 | 0.0142 | 0.0005 | 0.0000 | 0.0000 | 0.0002 | 0.0022 | 0.0071 | 0.0004 | 0.0000 | 0.0000 |
| % solvent-accessible amino acid residues | 1.426 | 1.3478 | 0.0338 | 0.0086 | 0.0318 | 0.0009 | 0.0003 | 0.0002 | 0.0003 | 0.0000 | 0.0027 | 0.0000 |
| % intrinsically disordered regions | 2.043 | 1.9310 | 0.0458 | 0.0032 | 0.0623 | 0.0005 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 |
| % Pfam domain | 1.328 | 1.2830 | 0.0294 | 0.0016 | 0.0069 | 0.0004 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0066 | 0.0000 |
| Exon feature category | Subtotal | |||||||||||
| Structural-functional features | 4.798 | 4.562 | 0.109 | 0.014 | 0.101 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 | 0.009 | 0.000 |
| Splicing features | 1.822 | 0.907 | 0.915 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Exon length | 0.753 | 0.596 | 0.031 | 0.117 | 0.005 | 0.003 | 0.000 | 0.000 | 0.000 | 0.001 | 0.000 | 0.000 |
| Expression level | 0.423 | 0.272 | 0.020 | 0.125 | 0.001 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Compactness features | 0.121 | 0.097 | 0.000 | 0.004 | 0.000 | 0.000 | 0.005 | 0.005 | 0.002 | 0.008 | 0.000 | 0.000 |
| Other features | 0.080 | 0.032 | 0.015 | 0.011 | 0.002 | 0.000 | 0.005 | 0.005 | 0.008 | 0.002 | 0.000 | 0.000 |