Table S2.
The within-gene variance in exonic dN explained by the principal components broken down to eleven exon features (upper half); or to six feature categories (lower half).
| Var. explained | Comp 1 | Comp 2 | Comp 9 | Comp 3 | Comp 10 | Comp 7 | Comp 6 | Comp 4 | Comp 5 | Comp 11 | Comp 8 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exon features | (Sub)total | |||||||||||
| 13.49 | 9.38 | 2.33 | 0.7 | 0.52 | 0.24 | 0.21 | 0.05 | 0.02 | 0.02 | 0.02 | 0.00 | |
| ASE/CSE exon type | 1.650 | 0.6580 | 0.9809 | 0.0000 | 0.0010 | 0.0000 | 0.0002 | 0.0000 | 0.0000 | 0.0001 | 0.0100 | 0.0000 |
| Weighted exon frequency (WEF) | 1.643 | 0.6580 | 0.9739 | 0.0000 | 0.0010 | 0.0000 | 0.0002 | 0.0001 | 0.0000 | 0.0001 | 0.0100 | 0.0000 |
| Average exonic expression level | 1.000 | 0.3948 | 0.0419 | 0.3234 | 0.2361 | 0.0031 | 0.0000 | 0.0003 | 0.0000 | 0.0001 | 0.0000 | 0.0000 |
| 5′ intron length | 0.235 | 0.1316 | 0.0000 | 0.0014 | 0.0088 | 0.0002 | 0.0760 | 0.0081 | 0.0018 | 0.0066 | 0.0000 | 0.0000 |
| 3′ intron length | 0.113 | 0.0094 | 0.0000 | 0.0084 | 0.0016 | 0.0002 | 0.0817 | 0.0001 | 0.0084 | 0.0032 | 0.0000 | 0.0000 |
| Exon length | 1.430 | 0.8648 | 0.0652 | 0.3038 | 0.1716 | 0.0110 | 0.0132 | 0.0000 | 0.0001 | 0.0000 | 0.0000 | 0.0000 |
| G+C content | 0.136 | 0.0470 | 0.0023 | 0.0266 | 0.0088 | 0.0048 | 0.0279 | 0.0045 | 0.0086 | 0.0050 | 0.0000 | 0.0000 |
| Exon duplicability | 0.080 | 0.0000 | 0.0303 | 0.0014 | 0.0005 | 0.0000 | 0.0074 | 0.0354 | 0.0004 | 0.0043 | 0.0000 | 0.0000 |
| % solvent-accessible amino acid residues | 2.167 | 1.9552 | 0.0722 | 0.0224 | 0.0452 | 0.0694 | 0.0000 | 0.0015 | 0.0006 | 0.0005 | 0.0000 | 0.0000 |
| % intrinsically disordered regions | 3.071 | 2.8012 | 0.0979 | 0.0084 | 0.0276 | 0.1358 | 0.0004 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
| % Pfam domain | 1.964 | 1.8612 | 0.0629 | 0.0042 | 0.0182 | 0.0151 | 0.0027 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
| Exon feature category | Subtotal | |||||||||||
| Structural-functional features | 7.203 | 6.618 | 0.233 | 0.035 | 0.091 | 0.220 | 0.003 | 0.002 | 0.001 | 0.001 | 0.000 | 0.000 |
| Splicing features | 3.294 | 1.316 | 1.955 | 0.000 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.020 | 0.000 |
| Exon length | 1.430 | 0.865 | 0.065 | 0.304 | 0.172 | 0.011 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Expression level | 1.000 | 0.395 | 0.042 | 0.323 | 0.236 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Compactness features | 0.348 | 0.141 | 0.000 | 0.010 | 0.010 | 0.000 | 0.158 | 0.008 | 0.010 | 0.010 | 0.000 | 0.000 |
| Other features | 0.215 | 0.047 | 0.033 | 0.028 | 0.009 | 0.005 | 0.035 | 0.040 | 0.009 | 0.009 | 0.000 | 0.000 |