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. 2012 Jul 4;8:389–415. doi: 10.4137/EBO.S9743

Table S6.

The between-gene variance in exonic dS explained by the principal components broken down to eleven exon features (upper half); or to six feature categories (lower half).

Var. explained Comp 3 Comp 1 Comp 9 Comp 6 Comp 8 Comp 5 Comp 7 Comp 2 Comp 4 Comp 10 Comp 11
Exon features (Sub)total
2.991 1.329 0.411 0.298 0.247 0.239 0.198 0.112 0.073 0.043 0.038 0.004
ASE/CSE exon type 0.040 0.0003 0.0011 0.0000 0.0008 0.0001 0.0002 0.0000 0.0355 0.0002 0.0000 0.0018
Weighted exon frequency (WEF) 0.041 0.0011 0.0014 0.0000 0.0009 0.0000 0.0000 0.0000 0.0354 0.0002 0.0000 0.0018
Average exonic expression level 0.726 0.5426 0.0388 0.1430 0.0006 0.0003 0.0005 0.0003 0.0001 0.0002 0.0001 0.0000
5′ intron length 0.113 0.0023 0.0074 0.0001 0.0153 0.0002 0.0160 0.0584 0.0006 0.0133 0.0000 0.0000
3′ intron length 0.107 0.0043 0.0033 0.0024 0.0082 0.0011 0.0197 0.0513 0.0003 0.0169 0.0000 0.0000
Exon length 0.559 0.3432 0.0564 0.1254 0.0063 0.0121 0.0141 0.0002 0.0004 0.0003 0.0010 0.0000
G+C content 0.296 0.1248 0.0000 0.0183 0.0872 0.0034 0.0529 0.0004 0.0000 0.0087 0.0005 0.0000
Exon duplicability 0.223 0.0074 0.0042 0.0000 0.1189 0.0000 0.0910 0.0006 0.0003 0.0006 0.0000 0.0000
% solvent-accessible amino acid residues 0.349 0.1699 0.0769 0.0075 0.0084 0.0716 0.0024 0.0001 0.0002 0.0027 0.0094 0.0000
% intrinsically disordered regions 0.251 0.1008 0.1240 0.0006 0.0001 0.0014 0.0009 0.0000 0.0001 0.0003 0.0229 0.0000
% Pfam domain 0.283 0.0321 0.0972 0.0002 0.0001 0.1488 0.0005 0.0003 0.0001 0.0000 0.0042 0.0000
Exon feature category Subtotal
Structural-functional features 0.884 0.303 0.298 0.008 0.009 0.222 0.004 0.000 0.000 0.003 0.037 0.000
expression level 0.726 0.543 0.039 0.143 0.001 0.000 0.001 0.000 0.000 0.000 0.000 0.000
exon length 0.559 0.343 0.056 0.125 0.006 0.012 0.014 0.000 0.000 0.000 0.001 0.000
Other features 0.519 0.132 0.004 0.018 0.206 0.003 0.144 0.001 0.000 0.009 0.001 0.000
Compactness features 0.221 0.007 0.011 0.002 0.023 0.001 0.036 0.110 0.001 0.030 0.000 0.000
Splicing features 0.081 0.001 0.002 0.000 0.002 0.000 0.000 0.000 0.071 0.000 0.000 0.004