Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Figure 2. Schematic diagram depicting PrPC regulation of BACE1 in sporadic AD brains. In the healthy brain, PrPC interacts with BACE1 inhibiting its cleavage of APP and thereby keeping the level of Aβ in check. In sporadic AD, PrPC levels are reduced, leading to impaired BACE1 inhibition and increased Aβ formation.
