Table 1.
T Cell Responses Mapped in Acute HIV-1 Infection (Day 18 from Admission)
| Virus | Protein | Sequence | IFN-γ ELISPOT (SFU/106PBMC) | Tetramer frequency (% of CD3/CD8 T cells) | Restriction |
|---|---|---|---|---|---|
| HIV-1 | GP160(585–593)a | RYLKDQQLL | 4220 | ND | CW*0702 |
| HIV | Integrase (263–271) | RKAKIIRDY | 2255 | ND | B*1503 |
| HIV | NEF (135–143) | YPLTFGWCY | 9180 | 9.0% | B*0702 |
| HIV | ENV (637–645) | NYTSLIYNL | 4615 | ND | CW*0702 |
| HCMV | pp65 (415–429)b | TPRVTGGGAM | 160 | ND | B*07 |
a
Amino acid alignment relative to HXB2 strain.
b
Alignment relative to HCMV AD169 strain.
IFN-γ, interferon gamma; PBMC, peripheral blood mononuclear cells.