Table 3.
Genotype Distributions and Statistical Comparisons of NKG2C Genotypes in Control and HIV Patients
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Genotype distributions | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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|
HIV-infected patient |
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| |
|
|
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|
Risk category |
Pretreatment virus load (copies/ml) |
||||||
| Control | All | IVDA | MSM | <30,000 | >30,000 | |||||||
| −/− | 13 | 5% | 33 | 8% | 6 | 7% | 10 | 6% | 5 | 11% | 8 | 13% |
| +/− | 71 | 25% | 130 | 30% | 19 | 20% | 60 | 34% | 8 | 17% | 25 | 39% |
| +/+ | 196 | 70% | 270 | 62% | 68 | 73% | 105 | 60% | 34 | 72% | 31 | 48% |
| |
|
|
|
Progression category |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LTNP | NP | STP | Other | |||||||||
| −/− | 5 | 9% | 9 | 7% | 7 | 6% | 11 | 9% | ||||
| +/− | 11 | 19% | 44 | 36% | 33 | 29% | 37 | 30% | ||||
| +/+ | 42 | 72% | 68 | 56% | 74 | 65% | 75 | 81% | ||||
|
Statistical comparisons | |||||||
|---|---|---|---|---|---|---|---|
| Comparison | Genotype | Significance | Odds ratio | 95% CI | |||
| Control vs. HIV | −/− | vs. | −/+ and +/+ | NS | 0.59 | 0.31 to 1.14 | |
| −/− and −/+ | vs. | +/+ | * | p=0.037 | 0.71 | 0.52 to 0.98 | |
| IVDA vs. MSM | −/− | vs. | −/+ and +/+ | NS | 1.34 | 0.40 to 3.24 | |
| −/− and −/+ | vs. | +/+ | * | p=0.044 | 0.55 | 0.32 to 0.96 | |
| LTNP vs. NP | −/− | vs. | −/+ and +/+ | NS | 1.17 | 0.38 to 3.68 | |
| −/− and −/+ | vs. | +/+ | * | p=0.049 | 0.49 | 0.25 to 0.96 | |
| LTNP vs. STP+NP | −/− | vs. | −/+ and +/+ | NS | 1.29 | 0.45 to 3.68 | |
| −/− and −/+ | vs. | +/+ | - | p=0.097 | 0.58 | 0.31 to 1.10 | |
| LTNP vs. rest | −/− | vs. | −/+ and +/+ | NS | 1.16 | 0.43 to 3.14 | |
| −/− and −/+ | vs. | +/+ | - | p=0.108 | 0.59 | 0.32 to 1.08 | |
| <30,000 vs. >30,000 (copies/ml) | −/− | vs. | −/+ and +/+ | NS | 0.83 | 0.25 to 2.73 | |
| −/− and −/+ | vs. | +/+ | * | p=0.019 | 2.78 | 1.24 to 6.23 | |
IVDA, intravenous drug abuse; MSM, men who have sex with men; LTNP, long-term nonprogressor; NP, normal progressor; STP, short-term progressor; OR, odds ratio; CI, confidence interval.