Table 3.
Annual changes in thoracic vertebral BMD, lung function, and LAA%
| Exacerbation (−) | p-value (within group) | Exacerbation (+) | p -value (within group) | p-value (between groups) | |||
|---|---|---|---|---|---|---|---|
| BMD, mg/ml | −0.30 | (−1.82, 1.33) | 0.41 | −3.78 | (−5.81, −0.29) | 0.002 | 0.01 |
| BMD/base, % | −0.60 | (−3.07, 2.63) | 0.39 | −5.41 | (−10.6, −0.36) | 0.002 | 0.02 |
| BMI | 0.00 | (−0.53, 0.38) | 0.65 | −0.78 | (−1.49, 0.70) | 0.34 | 0.38 |
| FEV1, mL | −51.4 | (−117.0, −7.7) | 0.0001 | −75.0 | (−97.9, −4.7) | 0.0005 | 0.72 |
| %FEV1, % | 0.28 | (−2.08,2.15) | 0.74 | 0.00 | (−1.72, 1.58) | 0.91 | 0.85 |
| DLCO /VA, mL/min/mmHg/L | −0.13 | (−0.32, 0.03) | 0.01 | −0.15 | (−0.26, 0.03) | 0.10 | 1.00 |
| LAA% (−960), % | 0.12 | (−0.61, 1.27) | 0.43 | 1.32 | (−4.78, 1.31) | 0.0005 | 0.01 |
| PaO2, mmHg | −0.48 | (−2.42, 1.80) | 0.91 | −1.00 | (−4.78, 1.32) | 0.20 | 0.29 |
Data are expressed as the median (25th, 75th percentile). BMD, bone mineral density in thoracic vertebrae ; BMD/base, percentage change in BMD compared with baseline BMD; FEV1, forced expiratory volume in 1 second; %FEV1, FEV1 % predicted DLCO /VA, ratio of diffusing capacity to alveolar ventilation; LAA%, percentage of low attenuation area.