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EMSA analyzes of RPA binding activity using dsDNA and ssDNA substrates in the presence of NSC15520. RPA was pre-incubated with inhibitor at 0, 400 μM, 200 μM, 100 μM, 50 μM and 25 μM, respectively. (A) Inhibition of dsDNA binding and helix destabilization by NSC 15520. RPA binds efficiently to the resulting ssDNA after the dsDNA substrate is denatured. (B) NSC15520 does not inhibit binding of RPA to ssDNA substrate.
