Table 4.
Unadjusted and adjusted event rates per 100 000 patient years associated with stimulant use in children and young people with mental health diagnosis
| Primary endpoint* | Secondary endpoint† | ||||
|---|---|---|---|---|---|
| Unadjusted | Adjusted‡ | Unadjusted | Adjusted‡ | ||
| Full cohort: | |||||
| Non-use | 3.5 (2.7 to 4.6) | Reference | 5.0 (4.0 to 6.2) | Reference | |
| Current use | 1.7 (0.8 to 3.5) | 2.2 (1.0 to 5.1) | 2.6 (1.5 to 4.8) | 3.7 (1.9 to 7.3) | |
| Former use | 1.5 (0.7 to 3.4) | 2.0 (0.8 to 4.9) | 2.3 (1.2 to 4.3) | 3.2 (1.5 to 6.5) | |
| Low risk cohort: | |||||
| Non-use | 2.1 (1.5 to 3.0) | Reference | 3.1 (2.3 to 4.2) | Reference | |
| Current use | 1.0 (0.4 to 2.6) | 1.0 (0.3 to 3.1) | 1.5 (0.7 to 3.3) | 1.6 (0.7 to 4.0) | |
| Former use | 1.3 (0.5 to 3.1) | 1.5 (0.6 to 4.0) | 2.0 (1.0 to 4.1) | 2.4 (1.1 to 5.2) | |
| High risk cohort: | |||||
| Non-use | 75.2 (49.5 to 114.1) | Reference | 99.1 (68.9 to 142.6) | Reference | |
| Current use | 51.5 (16.6 to 159.7) | 76.7 (21.0 to 277.3) | 85.8 (35.7 to 206.2) | 154.6 (55.5 to 430.0) | |
| Former use | 17.0 (2.4 to 120.5) | 24.1 (3.1 to 183.4) | 17.0 (2.4 to 120.5) | 27.7 (4.0 to 208.1) | |
| Injury censored cohort: | |||||
| Non-use | 2.4 (1.7 to 3.4) | Reference | 3.4 (2.6 to 4.6) | Reference | |
| Current use | 1.2 (0.5 to 3.3) | 1.6 (0.5 to 4.8) | 1.5 (0.6 to 3.7) | 2.1 (0.8 to 5.7) | |
| Former use | 1.0 (0.3 to 3.0) | 1.3 (0.4 to 4.3) | 1.6 (0.7 to 3.9) | 2.2 (1.1 to 4.5) | |
*Sudden cardiac death, acute myocardial infarction, stroke.
†Sudden cardiac death, acute myocardial infarction, stroke, ventricular arrhythmia
‡Calculated by multiplying crude event rate of non-users by respective adjusted odds ratios.