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. Author manuscript; available in PMC: 2012 Jul 18.
Published in final edited form as: J Nat Prod. 2012 Jan 24;75(2):167–174. doi: 10.1021/np200722w

Figure 1.

Figure 1

Structure and sequence diversity of cyclotides. The structure of the typical cyclotide kalata B1 is shown in gray. The six conserved cysteines are labeled with roman numerals, and the resulting cystine knot disulfide connectivity (CI–CIV, CII–CV, and CIII–CVI) is shown in yellow. The amino acid sequence and disulfide connectivity of kalata B1 are shown below the structure. The numbers (n) indicate the possible length (in amino acids) of the intercysteine loops comprising all currently known cyclotides (according to Ireland et al.61). The intercysteine loops can tolerate a wide variety of amino acid substitutions and are an indicator of the combinatorial diversity of the cyclotide scaffold.