|
Secondary structure
|
PSIPRED (v2.0) [81] and SSPRO (v4.0) [82]
|
assist 3D structure and domain boundary prediction |
|
Disordered or flexible region
|
DISEMBL (v1.5) [83], DISPRO (v1.0) [84] and DISOPRED (v2.0) [85]
|
assist 3D structure modeling and indicate the domain boundaries |
|
Transmembrane helix
|
TMHMM (v2.0), TOPPRED (v2.0), HMMTOP (v2.0), MEMSAT (v3.0), MEMSATSVM and Phobius |
predict subcellular localization; provide hints to the protein function. predict the topology of membrane proteins |
|
Signal peptide
|
SignalP (v3.0), Phobius and MEMSATSVM |
predict secreted proteins that could potentially be virulence factors |
|
Low-complexity
|
SEG [86]
|
Reveal false positive hits of homology search caused by matching of low-complexity region |
|
Coiled coil
|
COILS [87]
|
reveal false positive hits of homology search caused by matching of non-homologous coiled coils |
|
Conservation
|
PSI-BLAST, AL2CO |
reveal essential residues for the folding and function of a protein |
