Table 1. MAF–Gene Region 1^*.

Method	N	Min	Q1	Median	Q3	Max	Mean	SD
Hapgen	14500	−0.074	−0.010	−0.001	0.009	0.068	−0.001	0.017
Resampling	14500	−0.047	−0.005	<0.001	0.004	0.033	<0.001	0.008
HapSim	14300**	−0.042	−0.005	<0.001	0.004	0.038	<0.001	0.008

^*Change in MAF from original HapMap MAF for each pair of SNPs in Gene.

Region 1 (MAF_simulated – MAF_HapMap).

^**HapSim requires that all monoallelic SNPs are removed prior to simulation.