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. 2012 Jul 18;7(7):e41007. doi: 10.1371/journal.pone.0041007

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Yamaguchi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Reprogramming efficiency of fibroblasts (MEF, NB fb, 1wk fb and Adult fb), hematopoietic cells (FL CD45, HSC, HPC, MP and Mac) by four reprogramming factors including c-Myc. (B) Cell proliferation rate of fibroblasts (MEF, NB fb, 1wk fb and Adult fb) at three, four and five days after seeded in the absence of Dox (left) and in the presence of Dox (right). (C) Reprogramming efficiency of MEF were compared between reprogrammed by three factors (Oct4, Klf4 and Sox2), four factors (Oct4, Klf4, Sox2 and c-Myc) and three factors plus VPA (0.5 mM, 1 mM and 2 mM).