Table 1. 2′O-methyl Antisense Oligoribonucleotides.
Name | Length | Target region | Sequence (5′–3′) | GC | Tm |
40 | 15 | D2: 40–26 | mUmUmCmAAGUUGCAmCmGmUmU | 40 | 47 |
55 | 16 | D2: 55–40 | mAmAmGmACCAGGCGGmAmGmUmU | 56 | 57 |
66 | 16 | D2: 66–51 | mCmUmAmGACCUGGAAmAmGmAmC | 50 | 46 |
83 | 15 | D2: 83–68 | mUmAmCmAAAGUGUUmAmCmCmC | 40 | 47 |
104 | 19 | D3: 104–85 | mCmGmAmGCGUGGAGCCAAAmCmAmCmA | 60 | 60 |
118 | 14 | D3: 118–105 | mAmCmUmCGCCAGUmGmGmAmU | 57 | 59 |
135 | 18 | D3: 135–118 | mAmCmAmGUGCUGUUACUmAmAmCmA | 39 | 55 |
154 | 18 | D3: 154–138 | mUmCmAmUGCUCCGCUACmGmAmAmG | 56 | 58 |
164 | 14 | D3: 164–150 | mCmCmAmCGGCCGUmCmAmUmG | 71 | 54 |
176 | 14 | D3: 176–163 | mAmAmGmGAGGAGUmUmCmCmC | 57 | 56 |
183 | 17 | D3: 183–16717nt | mUmGmUmUACCAAGGAGmGmAmGmU | 47 | 46 |
192 | 15 | D3: 192–178 | mGmUmGmGGUCCUUGmUmUmAmC | 54 | 46 |
207 | 17 | D3: 207–191 | mGmUmGmGCUUUUGGCCmCmCmGmU | 65 | 64 |
213 | 15 | D3: 213–199 | mGmUmGmGGCGUGGCmUmUmUmU | 60 | 53 |
226 | 17 | D3: 226–210 | mAmUmGACGGGCCCGUmGmUmGmG | 71 | 58 |
247 | 16 | D3: 247–233 | mUmCmGmCCGUGCUGGmGmGmUmU | 69 | 61 |
265 | 17 | D3: 265–249 | mUmGmGmGUUUCGCAGUmAmAmAmG | 47 | 56 |
282 | 18 | D3: 282–265 | mUmCmAmAUGUCACUUUAmAmAmGmU | 27 | 45 |
300 | 17 | D3: 300–284 | mAmGmUmGUGUGGGUACmCmAmGmU | 53 | 62 |
317 | 17 | D4: 317–301 | mAmUmCmCUUAGCCUGUmCmAmCmC | 53 | 62 |
331 | 16 | D4: 331–317 | mGmGmGmUACCUGAAGmGmGmCmA | 63 | 60 |
349 | 18 | D4: 349–334 | mAmGmUmGUCGCGUGUUAmCmCmUmC | 56 | 61 |
360 | 18 | D4: 361–344 | mUmCmAmGAUCCCGAGUGmUmCmGmC | 61 | 63 |
384 | 18 | D4: 384–367 | mUmUmAmUAGAAGCCCCAmGmUmCmC | 50 | 56 |
397 | 18 | D4: 397–378 | mAmAmCmCGAGCGCUUUUmAmUmAmG | 44 | 53 |
407 | 16 | D4: 407–392 | mGmAmAmGCUUUUUAAmAmCmCmG | 38 | 44 |
419 | 17 | D4: 419–404 | mUmAmUmUCAGGCAUAGmAmAmGmC | 41 | 49 |
432 | 17 | D5: 432–415 | mCmCmUmCCGGUCACCUmAmUmUmC | 59 | 59 |
452 | 19 | D5: 452–433 | mUmUmGmUAAAGGAAAGGUmGmCmCmG | 47 | 48 |
AUG AUG | 18 | luciferase AUG | mCmUmUmCCAUUUUACCAmAmCmAmG | 39 | 49 |
AUG1 AUG1 | 19 | FMDV AUG1 | mCmAmGmUUGUAUUCAUAGmGmGmUmC | 42 | 52 |
AUG2 | 18 | FMDV AUG2 | mGmAmAmUUCCAUUUUUCmCmUmGmC | 39 | 52 |
SCR | 16 | Random sequence | mUmGmCmAGCUGACAGmUmGmUmA | 50 | 57 |
2-O′methyl modifications are designated with a letter ¨m̈. GC, content of GC, Tm, melting temperature.