Table 1. 2′O-methyl Antisense Oligoribonucleotides.

Name	Length	Target region	Sequence (5′–3′)	GC	Tm
40	15	D2: 40–26	mUmUmCmAAGUUGCAmCmGmUmU	40	47
55	16	D2: 55–40	mAmAmGmACCAGGCGGmAmGmUmU	56	57
66	16	D2: 66–51	mCmUmAmGACCUGGAAmAmGmAmC	50	46
83	15	D2: 83–68	mUmAmCmAAAGUGUUmAmCmCmC	40	47
104	19	D3: 104–85	mCmGmAmGCGUGGAGCCAAAmCmAmCmA	60	60
118	14	D3: 118–105	mAmCmUmCGCCAGUmGmGmAmU	57	59
135	18	D3: 135–118	mAmCmAmGUGCUGUUACUmAmAmCmA	39	55
154	18	D3: 154–138	mUmCmAmUGCUCCGCUACmGmAmAmG	56	58
164	14	D3: 164–150	mCmCmAmCGGCCGUmCmAmUmG	71	54
176	14	D3: 176–163	mAmAmGmGAGGAGUmUmCmCmC	57	56
183	17	D3: 183–16717nt	mUmGmUmUACCAAGGAGmGmAmGmU	47	46
192	15	D3: 192–178	mGmUmGmGGUCCUUGmUmUmAmC	54	46
207	17	D3: 207–191	mGmUmGmGCUUUUGGCCmCmCmGmU	65	64
213	15	D3: 213–199	mGmUmGmGGCGUGGCmUmUmUmU	60	53
226	17	D3: 226–210	mAmUmGACGGGCCCGUmGmUmGmG	71	58
247	16	D3: 247–233	mUmCmGmCCGUGCUGGmGmGmUmU	69	61
265	17	D3: 265–249	mUmGmGmGUUUCGCAGUmAmAmAmG	47	56
282	18	D3: 282–265	mUmCmAmAUGUCACUUUAmAmAmGmU	27	45
300	17	D3: 300–284	mAmGmUmGUGUGGGUACmCmAmGmU	53	62
317	17	D4: 317–301	mAmUmCmCUUAGCCUGUmCmAmCmC	53	62
331	16	D4: 331–317	mGmGmGmUACCUGAAGmGmGmCmA	63	60
349	18	D4: 349–334	mAmGmUmGUCGCGUGUUAmCmCmUmC	56	61
360	18	D4: 361–344	mUmCmAmGAUCCCGAGUGmUmCmGmC	61	63
384	18	D4: 384–367	mUmUmAmUAGAAGCCCCAmGmUmCmC	50	56
397	18	D4: 397–378	mAmAmCmCGAGCGCUUUUmAmUmAmG	44	53
407	16	D4: 407–392	mGmAmAmGCUUUUUAAmAmCmCmG	38	44
419	17	D4: 419–404	mUmAmUmUCAGGCAUAGmAmAmGmC	41	49
432	17	D5: 432–415	mCmCmUmCCGGUCACCUmAmUmUmC	59	59
452	19	D5: 452–433	mUmUmGmUAAAGGAAAGGUmGmCmCmG	47	48
AUG AUG	18	luciferase AUG	mCmUmUmCCAUUUUACCAmAmCmAmG	39	49
AUG1 AUG1	19	FMDV AUG1	mCmAmGmUUGUAUUCAUAGmGmGmUmC	42	52
AUG2	18	FMDV AUG2	mGmAmAmUUCCAUUUUUCmCmUmGmC	39	52
SCR	16	Random sequence	mUmGmCmAGCUGACAGmUmGmUmA	50	57

2-O′methyl modifications are designated with a letter ¨m̈. GC, content of GC, Tm, melting temperature.