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. 2012 Jul 18;7(7):e40787. doi: 10.1371/journal.pone.0040787

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Zamanian et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The general set of experimental outcomes for an RNAi-based deorphanization experiment focused on the G and G pathway are shown. Letters and each represent cAMP datasets for particular treatment conditions. Potential results are described with respect to the notion that a given ligand may act on multiple GPCRs that are not necessarily coupled to the same G protein (G or G). Abbreviations: NT, no treatment; Fk, forskolin; L, ligand; R, receptor; RNAi-control, control membrane preparation; RNAi-R, R-suppressed membrane preparation; , cAMP measurement variable. Asterisks (*) are used to denote normalized data.

Inline graphic — The general set of experimental outcomes for an RNAi-based deorphanization experiment focused on the G and G pathway are shown. Letters and each represent cAMP datasets for particular treatment conditions. Potential results are described with respect to the notion that a given ligand may act on multiple GPCRs that are not necessarily coupled to the same G protein (G or G). Abbreviations: NT, no treatment; Fk, forskolin; L, ligand; R, receptor; RNAi-control, control membrane preparation; RNAi-R, R-suppressed membrane preparation; , cAMP measurement variable. Asterisks (*) are used to denote normalized data.