Table 1. Description of the different doses, routes, and regimens utilized for rhGAA and AT2220 administration.
Figure | Species | Age (weeks) | rhGAA (mg/kg) | AT2220(mg/kg) | Route of Administration/Timing | Number of Administrations |
2A | SD rats | 8 | 10 | 3 and 30 | AT2220 PO 30 minutes prior to rhGAA IV bolus | Single |
2B | SD rats | 8 | 10 | 3 and 30 | AT2220 PO 30 minutes prior to rhGAA IV infusion | Single |
3, 4, and 6 | GAA KO mice | 12 | 20 | 30 | AT2220 PO 30 minutes prior to rhGAA IV bolus | Four bi-weekly |
5 | GAA KO mice | 12 | 20 | 10 and 30 | AT2220 PO 30 minutes prior to rhGAA IV bolus | Four bi-weekly |
SD, Sprague Dawley.