Table 1. Description of the different doses, routes, and regimens utilized for rhGAA and AT2220 administration.

Figure	Species	Age (weeks)	rhGAA (mg/kg)	AT2220(mg/kg)	Route of Administration/Timing	Number of Administrations
2A	SD rats	8	10	3 and 30	AT2220 PO 30 minutes prior to rhGAA IV bolus	Single
2B	SD rats	8	10	3 and 30	AT2220 PO 30 minutes prior to rhGAA IV infusion	Single
3, 4, and 6	GAA KO mice	12	20	30	AT2220 PO 30 minutes prior to rhGAA IV bolus	Four bi-weekly
5	GAA KO mice	12	20	10 and 30	AT2220 PO 30 minutes prior to rhGAA IV bolus	Four bi-weekly

SD, Sprague Dawley.