Table 4.

Variation of within-pair methylation discordance over the full adult lifespan

	Baseline estimate of variation as SD (% methylation)‡	Increase in variation per decade
Locus†		Proportional increase§ (%)	P¶
Global	2.2	9.1	3.4 × 10−06
KCNQ1OT1	1.9	11.4	0.002
GNASAS	3.5	2.7	0.415
IGF2DMR	4.4	11.1	3.8 × 10−09
LEP	4.8	16.0	2.0 × 10−08
CRH	8.4	8.0	8.9 × 10−06

^†Loci are ordered from top to bottom as in Fig. 1B from left to right.

^‡The SD of discordance at baseline, estimated from the residual variance and the random effect intercept of the linear mixed model.

^§The proportional (in percentage) increase in variation of discordance each decade, estimated from the random effect of age.

^¶One-sided P-value from a Z-test on the random effect estimate of age from the same linear mixed model.