Table 2.
Physicochemical characterization of PTX-loaded PEG3.5K-EB2 micelles
| PEG3.5K-EB2:PTX (m/m) |
concentration of PTX in micelles (mg/mL) |
DLCa (%) |
DLEb (%) |
zetac (mV) |
|---|---|---|---|---|
| 2.5:1 | 1.07 | 7.51 | 79.9 | 1.58±0.37 |
| 5:1 | 1.07 | 3.90 | 96.7 | 1.89±0.08 |
| 7.5:1 | 1.07 | 2.63 | 98.6 | −1.52±0.20 |
| 2.14 | 2.63 | 97.5 | −1.29±0.19 | |
| 3.21 | 2.63 | 81.3 | −2.64±0.43 |
a
DLC = drug loading capacity
b
DLE = drug loading efficiency
c
Measured by dynamic light scattering particle sizer (Zetasizer) Values reported are the means ± SD for triplicate samples.