Table II.
Gestational factors in relation to rhabdoid tumors
| Control | All cases (n=105) | Rhabdoid sarcomasa (n=61) | AT/RT (n=44) | ||||
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | Adjusted OR (95% CI) b |
n (%) | Adjusted OR (95% CI) b |
n (%) | Adjusted OR (95% CI) b |
|
| Birthweight | |||||||
| <2500g | 12171 (5.9) | 14 (13.3) | 2.68 (1.51, 4.75) | 7 (11.5) | 2.43 (1.09, 5.41) | 7 (15.9) | 2.99 (1.31, 6.84) |
| 2500-3999g | 173415 (83.4) | 78 (74.3) | Referent | 48 (78.7) | Referent | 30 (68.2) | Referent |
| 4000g+ | 22397 (10.8) | 13 (12.4) | 1.41 (0.78, 2.54) | 6 (9.8) | 1.09 (0.46, 2.57) | 7 (15.9) | 1.93 (0.85, 4.43) |
| Gestational age | |||||||
| Preterm (<37 weeks) | 20240 (10.3) | 20 (20.4) | 2.32 (1.40, 3.87) | 12 (21.1) | 2.63 (1.34, 5.17) | 8 (19.5) | 1.97 (0.90, 4.27) |
| Term (37-42 weeks) | 168708 (85.6) | 72 (73.5) | Referent | 39 (68.4) | Referent | 33 (80.5) | Referent |
| Postterm (43+ weeks) | 8141 (4.1) | 6 (6.1) | 2.19 (0.95, 5.06) | 6 (10.5) | 3.66 (1.54, 8.71) | 0 (0) | ------- |
| Size for gestational age c | |||||||
| Small | 20645 (10.3) | 10 (10.2) | 1.08 (0.57, 2.03) | 6 (10.5) | 0.84 (0.33, 2.11) | 4 (9.8) | 1.46 (0.61, 3.50) |
| Normal | 156189 (78.2) | 76 (77.6) | Referent | 45 (78.9) | Referent | 31 (75.6) | Referent |
| Large | 22908 (11.5) | 12 (12.2) | 1.05 (0.54, 2.03) | 6 (10.5) | 1.08 (0.46, 2.54) | 6 (14.6) | 1.00 (0.35, 2.85) |
| Method of delivery | |||||||
| Vaginal | 158789 (76.3) | 73 (69.5) | Referent | 44 (72.1) | Referent | 29 (65.9) | Referent |
| Cesarean | 49259 (23.7) | 32 (30.5) | 1.25 (0.81, 1.92) | 17 (27.9) | 1.28 (0.71, 2.29) | 15 (34.1) | 1.19 (0.63, 2.23) |
| Multiple birth | |||||||
| Singleton | 203010 (97.5) | 96 (91.4) | Referent | 57 (93.4) | Referent | 39 (88.6) | Referent |
| Twins or more | 5167 (2.5) | 9 (8.6) | 3.25 (1.63, 6.49) | 4 (6.6) | 3.08 (1.11, 8.55) | 5 (11.4) | 3.16 (1.23, 8.13) |
| Start of prenatal care | |||||||
| 1st trimester | 164462 (80.0) | 89 (85.6) | Referent | 50 (83.3) | Referent | 39 (88.6) | Referent |
| No care or after 1st trimester |
41029 (20.0) | 15 (14.4) | 1.02 (0.57, 1.83) | 10 (16.7) | 0.90 (0.43, 1.89) | 5 (11.4) | 1.13 (0.44, 2.94) |
| Parity | |||||||
| 0 | 81857 (39.3) | 43 (41.0) | Referent | 23 (37.7) | Referent | 20 (45.5) | Referent |
| 1 | 65078 (31.3) | 32 (30.5) | 0.90 (0.56, 1.45) | 21 (34.4) | 1.18 (0.63, 2.22) | 11 (25.0) | 0.63 (0.30, 1.32) |
| 2 or more | 61103 (29.4) | 30 (28.6) | 0.96 (0.57, 1.60) | 17 (27.9) | 1.04 (0.51, 2.13) | 13 (29.5) | 0.90 (0.43, 1.90) |
a
Rhabdoid sarcomas include renal tumors and extra-renal non-CNS tumors.
b
Odds ratios adjust for maternal age, maternal race/ethnicity, year of birth, and method of payment for prenatal care.
c
Size for gestational age was defined as small if birth weight was less than the 10th percentile and defined as large if greater than the 90th percentile of the birthweight standards for a given gestational age.