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. Author manuscript; available in PMC: 2013 Jul 18.
Published in final edited form as: J Am Chem Soc. 2012 Jul 10;134(28):11559–11572. doi: 10.1021/ja302269r

Scheme 2.

Scheme 2

Synthesis of 10 and 11a

a Reagents and conditions: (a) (i) n-BuLi, THF, −78 °C to rt, 2 h, (ii) NaH, DMF, 0 °C, 3 h, (iii) TBAF, DMF/THF, 0 °C, 2 h, (iv) PPh3, CBr4, CH2Cl2, 0 °C, 3 h, 26–43%; (b) (i) NaH, DMF, 0 °C, 3 h, (ii) 20 wt % Pd(OH)2/C, H2, EtOH, 60 °C, 36 h, 84–89%; (c) 3N HCl/MeOH, rt, 24 h, 89–94%.