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. Author manuscript; available in PMC: 2013 Jul 18.
Published in final edited form as: J Am Chem Soc. 2012 Jul 10;134(28):11559–11572. doi: 10.1021/ja302269r

Table 1.

Inhibition of NOS isozymes by the enantiomerically pure isomers of 1–3

Compounds Ki (μM)a Selectivitya
nNOS eNOS iNOS n/e n/i
1a 0.052 26.4 3.8 506 74
1b 0.005 20.3 3.9 3830 743
2a 0.116 26.2 7.5 226 65
2b 0.007 19.2 5.8 2667 806
(±)-3 0.080 62.0 52.0 780 650
a

n/e and n/i are the selectivity ratio of Ki (eNOS or iNOS) to Ki (nNOS).