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. Author manuscript; available in PMC: 2013 Jul 18.
Published in final edited form as: J Am Chem Soc. 2012 Jul 10;134(28):11559–11572. doi: 10.1021/ja302269r

Table 2.

Inhibition of NOS isozymes by synthetic compounds 4–7

Compound Ki (μM)a
Selectivityb
nNOS eNOS iNOS n/e n/i
4a 9.057 34.0 468.5 4 52
4b 0.922 33.8 83.8 37 91
5a 15.402 69.0 133.8 4 9
5b 0.637 77.0 35.1 121 55
6 0.230 35.6 106.0 155 461
7 0.117 4.4 12.4 37 106
a

The apparent Ki values are represented as the mean of two or more independent experiments preformed in duplicate with five or six data points each.

b

n/e and n/i are the selectivity ratios of Ki (eNOS or iNOS) to Ki (nNOS).