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. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Shock. 2012 Aug;38(2):146–152. doi: 10.1097/SHK.0b013e31825ce0de

CpG-ODN (10ug/30g body weight) was intraperitoneally administered one hour before T-H. The PI3K inhibitor, LY 294002 (LY; 1mg/30g body weight) or ERK inhibitor, U0126 (312 µg/30 g body weight) were administered by intraperitoneal injection, 15 min prior to CpG-ODN administration. Hemodynamic parameters were measured before, during and 60 minutes after the initiation of hemorrhage. Mean AP: mean arterial pressure; LVDP: left ventricular developed pressure. Data were displayed as of percentage of before. Results were presented as mean ± SEM (N = 5–8/group). *P < 0.05 T-H vs. vehicle T-H; ^#P < 0.05 vs. CpG-ODN

CpG-ODN (10ug/30g body weight) was intraperitoneally administered one hour before T-H. The PI3K inhibitor, LY 294002 (LY; 1mg/30g body weight) or ERK inhibitor, U0126 (312 µg/30 g body weight) were administered by intraperitoneal injection, 15 min prior to CpG-ODN administration. Hemodynamic parameters were measured before, during and 60 minutes after the initiation of hemorrhage. Mean AP: mean arterial pressure; LVDP: left ventricular developed pressure. Data were displayed as of percentage of before. Results were presented as mean ± SEM (N = 5–8/group). *P < 0.05 T-H vs. vehicle T-H; ^#P < 0.05 vs. CpG-ODN