Table 2.
mGFR, eGFR and Difference (Error) at Baseline and Change Over Time
| Pooled (N=3531) |
MDRD (N=840) |
AASK (N=1094) |
CSG (N=360) |
DCCT (N=1237) |
|
|---|---|---|---|---|---|
| No. of subject-time measurements | 19735 | 8049 | 8649 | 998 | 2039 |
| Max no. of measurements per person | 15 | 15 | 15 | 6 | 3 |
| mGFR | |||||
| Baseline (Intercept) | 73.1 (71.6, 74.5); <0.001 | 33.0 (32.2, 33.8); <0.001 | 46.7 (45.8, 47.5); <0.001 | 74.6 (71.3, 78.0); <0.001 | 123.9 (122.7, 125.1); <0.001 |
| Change (Slope) | −2.25 (−2.43, −2.06); <0.001 | −3.34 (−3.59, −3.09); <0.001 | −1.89 (−2.10, −1.69); <0.001 | −5.25 (−6.27, −4.24); <0.001 | −0.94 (−1.40, −0.48); <0.001 |
| % Change (Slope) | −7.1% (−7.6, −6.6); <0.001 | −15.7% (−16.8, −14.5); <0.001 | −8.1% (−8.8, −7.3); <0.001 | −11.8% (−13.7, −10.0); <0.001 | −0.8% (−1.2, −0.4); <0.001 |
| eGFR | |||||
| Baseline (Intercept) | 72.7 (71.5, 74.0); <0.001 | 35.1 (34.2, 36.0); <0.001 | 50.8 (49.7, 51.8); <0.001 | 76.7 (73.8, 79.6); <0.001 | 117.3 (116.6, 118.0); <0.001 |
| Change (Slope) | −2.22 (−2.37, −2.07); <0.001 | −3.37 (−3.64, −3.09); <0.001 | −2.19 (−2.40, −1.99); <0.001 | −4.52 (−5.46, −3.57); <0.001 | −1.06 (−1.31, −0.80); <0.001 |
| % Change (Slope) | −7.1% (−7.6, −6.6); <0.001 | −15.5% (−16.7, −14.3); <0.001 | −8.4% (−9.2, −7.6); <0.001 | −0.10%(−11.7, −8.2); <0.001 | −1.0% (−1.2, −0.7); <0.001 |
| Difference (Error) | |||||
| Baseline (Intercept) | 0.14 (−0.35, 0.63); 0.6 | −2.10 (−2.47, −1.73); <0.001 | −4.04 (−4.56, −3.52); <0.001 | −2.05 (−3.82, −0.28); 0.02 | 6.58 (5.39, 7.77); <0.001 |
| Change (Slope) | −0.09 (−0.24, 0.05); 0.2 | 0.01 (−0.11, 0.14); 0.8 | 0.28 (0.15, 0.42); <0.001 | −0.71 (−1.49, 0.08); 0.08 | 0.11 (−0.38, 0.59); 0.7 |
| % Change (Slope) | −0.1% (−0.4, 0.1); 0.2 | −0.3% (−0.7, 0.1); 0.1 | 0.2% (−0.1, 0.5); 0.3 | −1.6% (−2.6, −0.5); 0.004 | 0.1% (−0.3, 0.6); 0.5 |
Except where indicated, values shown are given as estimate (95% CI); p. Unit for mGFR and eGFR and for the difference (error) is ml/min/1.73 m2. Unit for change is ml/min/1.73 m2 per year computed using non-log transformed values or % per year computed log transformed values. Intercepts for the model using log transformed values are not shown.
Max, maximum; MDRD - Modification of Diet in Renal Disease; AASK - African American Study of Kidney Disease and Hypertension; CSG Collaborative Study Group; DCCT - Diabetes Control and Complications Trial; eGFR, estimated glomerular filtration rate; mGFR, measured glomerular filtration rate