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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Dev Dyn. 2012 Jun 15;241(8):1260–1273. doi: 10.1002/dvdy.23811

Figure 10. Smurf1 and Smurf2 differentially regulate mesodermal marker expression.

Figure 10

A) Knockdown of Smurf2 in the marginal zone region caused expansion of the pan-mesodermal marker XBra towards the ectodermal region. Dorsal knockdown of Smurf2 reduced expression of chordin, whereas ventral knockdown of Smurf2 led to expansion of wnt8 into the ectodermal domain. B) Unlike Smurf2 knockdown, Smurf1 knockdown reduced the expression of both XBra and chordin, and double knockdown of both Smurfs resulted in more efficient reduction of these markers. The numbers indicate the embryos displaying the shown changes of marker expression.