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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Dev Dyn. 2012 Jun 15;241(8):1260–1273. doi: 10.1002/dvdy.23811

Figure 3. Elevation of Smurf levels affects neural and neural crest development.

Figure 3

A) Increased levels of Smurf2 led to expansion or ectopic expression of the neural genes Sox2, NRP1 and Pax6 and reduction of the epidermal marker XK70, but could both up- and down-regulate the neural plate border genes Slug and Pax3. B) Smurf1 and Smurf2 function similarly to control neural and neural crest development; and together they facilitated expansion of the neural genes but reduction of the neural crest marker Slug. The numbers of the embryos displaying the shown changes in marker expression are indicated in the figure.