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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Dev Dyn. 2012 Jun 15;241(8):1260–1273. doi: 10.1002/dvdy.23811

Figure 5. Smurf1 and Smurf2 differentially regulate mesodermal markers at gastrula stages.

Figure 5

A) Overexpression of Smurf2 in either DMZ or VMZ disrupts expression of the pan-mesodermal marker Brachyury (XBra). Dorsal expression of Smurf2 slightly reduces the dorsal mesoderm marker chordin, whereas ventral expression of Smurf2 inhibits the ventral-lateral mesodermal marker wnt8. B) Unlike Smurf2, Smurf1 does not block, but instead mildly expands, the expression of XBra or chordin; though like Smurf2, it also inhibits wnt8 expression. Co-expression of Smurf1 and 2 leads to reduction of all three mesodermal markers. The numbers indicate the embryos displaying the shown changes in marker expression.