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. Author manuscript; available in PMC: 2013 Jul 13.
Published in final edited form as: J Bone Miner Res. 2012 May;27(5):10.1002/jbmr.1551. doi: 10.1002/jbmr.1551

Figure 6. Targeted disruption of TRα and TRβ differentially modulates IGF-I expression in mice.

Figure 6

[A]: Serum IGF-I levels in homozygous and heterozygous TRα0/0 and TRβ mutant mice and corresponding WT littermates at 14 days of age. A = P<0.01 vs WT mice of the same genotype, B = P<0.01 vs heterozygous mice of the same genotype. N = 8–12 mice per genotype. [B-C]: IGF-I mRNA levels in the liver, bone, cartilage and muscle of homozygous and heterozygous TRα0/0 (B) and TRβ (C) mutant mice and corresponding WT littermate control mice at 14 days of age. Values are fold-change of WT control mice. A = P<0.01 vs WT mice of the same genotype, B = P<0.01 vs heterozygous mice of the same genotype. N = 8 mice per group. [D-F]: ALS (D), IGFBP-3 (E) and IGFBP-5 (F) mRNA levels in the liver of homozygous and heterozygous TRα0/0 and TRβ mutant mice and corresponding WT littermates at 14 days of age. A = P<0.01 vs WT mice of the same genotype, B = P<0.01 vs heterozygous mice of the same genotype. N = 8–12 mice per genotype.