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The lateral channel to the extracellular surface composing helices 5, 6 and 7. The H296-Y308-N293 hydrogen bond network of interactions in the β2 adrenergic receptor (A, B) along the ligand unbinding trajectories, radius of gyration of the lateral channel, along unbinding pathway C (C) and radius of gyration of the lateral channel in 30 nseconds classical MD of the ligand-receptor complexes (D).
