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. 2012 Jun 5;31(14):3130–3146. doi: 10.1038/emboj.2012.155

Figure 7.

Figure 7

Function of activated Pax5 target genes in pro-B and mature B cells. (A, B) Pie diagram indicating the different functional classes of activated Pax5 target genes in pro-B cells (A) and mature B cells (B). The activated Pax5 target genes shown below are ranked according to the significance of their differential expression as determined by RNA sequencing of Rag2−/− and Pax5-deficient pro-B cells (Figure 4D) or wild-type and Pax5-deficient mature B cells (Figure 6C). Genes with a significance value of >83 (>16-fold) or between 83 and 47 (16- to 8-fold) are indicated by red and green boxes, respectively, whereas the remaining genes are characterized by a significance value ranging from 47 to 20 (eight- to four-fold). Genes that are commonly activated in both cell types are indicated in bold, and genes with a known function in B lymphopoiesis are shown in blue. Signalling adaptors (A), kinases (K) and phosphatases (P) are indicated.