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. 2012 May 29;31(14):3147–3156. doi: 10.1038/emboj.2012.156

Figure 5.

Figure 5

Activation of PKC sensitizes KCNQ2 current to sequestering of PIP2 by neomycin. (A) PDBu application onto wild-type KCNQ2 current had little effect. The black box indicates the presence of 100 nM PDBu. (B) PDBu application induced current suppression of wild-type KCNQ2 current when neomycin was included in the patch pipette solution. (C) Relative KCNQ2 current amplitudes at t=2 min from KCNQ2 (wt) without neomycin shown in (A) (left), in the presence of neomycin, Neo Q2 (wt), shown in (B) (middle), and KCNQ2 (S541A) in the presence of neomycin (right). **<0.01 nonparametric ANOVA followed by t-test. Error bars indicate s.e.m.