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. 2012 May 29;31(14):3147–3156. doi: 10.1038/emboj.2012.156

Figure 7.

Figure 7

Schematic representation of KCNQ2 channel complex and a proposed channel complex rearrangement. KCNQ2 subunit of the M-channel tethers PIP2, CaM, AKAP79/150, and PKC. Activation of PLC by muscarinic stimulation depletes PIP2 and activates PKC, which phosphorylates KCNQ2 subunit. The phosphorylation of KCNQ2 at S541 located in the distal segment of the CaM-binding site induces dissociation of CaM from the KCNQ2 channel. Calmodulin-deficient KCNQ2 channel has lower affinity towards PIP2. Together with reduction of PIP2 induced by PLC activation, muscarinic stimulation generates profound suppression of the M-channel activity.