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. Author manuscript; available in PMC: 2012 Jul 19.
Published in final edited form as: J Allergy Clin Immunol. 2010 Jul;126(1):45–49. doi: 10.1016/j.jaci.2010.03.042

TABLE I.

Diagnostic criteria of HESs

Old definition: idiopathic hypereosinophilic syndrome Proposed new definition: HESs

  1. Blood eosinophilia of greater than 1500/mm3 for at least 6 mo

  2. Unknown trigger of eosinophilia

  3. Signs and symptoms of organ involvement

  1. Blood eosinophilia of greater than 1500/mm3 on at least 2 occasions or evidence of prominent tissue eosinophilia associated with symptoms and marked blood eosinophilia

  2. Exclusion of secondary causes of eosinophilia, such as parasitic or viral infections, allergic diseases, drug-induced or chemical-induced eosinophilia, hypoadrenalism, and neoplasms