Table 1.
Distribution characteristics of covariates used for simulated dataset
| Covariate | Source | Mean, expected (observed) | Standard deviation, expected (observed) |
|---|---|---|---|
| Body mass index (BMI) | Log normal | 26.0 kg/m2 (26.3) | 0.15 kg/m2 (0.156) |
| Sex (SEX) | Discreet (0,1) | – | 0.5 males, 0.5 females |
| (0.47 males, 0.53 females) | |||
| Age (AGE) | Normal | 40 years (38.8 years) | 8 years (8.18 years) |
| Creatinine (CR) | Log normal | 1.0 mg/Dl (0.98 mg/Dl) | 0.13 mg/DI (0.12 mg/DI) |
| Height (HT) | Mean of 1.7 for males, 1.5 for females | 1.6 m (1.59 m) | 0.2 m |
| Weighta (WT) | BMI × HT2 | 67.4 kg | 21.2 kg |
| Body-surface areaa (BSA) |
|
1.71 m2 | 0.363 m2 |
| Creatinine clearancea (CRCL) | (140 × AGE) × WT/(72 × CR) | 98 mL/min | 36 mL/min |
| Unrelated covariate 1 (CV1) | Log normal | 100 (97.3) | 0.3 (0.31) |
| Unrelated covariate 2 (CV2) | Log normal | 10 (10.1) | 0.4 (0.42) |
| Unrelated covariate 3 (CV3) | Log normal | 1.0 (0.99) | 0.2 (0.21) |
| Unrelated covariate 4 (CV4) | Log normal | 0.1 (0.096) | 0.2 (0.21) |
aThere is no expected mean or expected standard deviation for calculated covariates