Table 10.

Correlation matrix of simulated covariates and the NONMEM control file used for generation of simulated patient dataset

	BMI	HT	CR	AGE	WT	BSA	CRCL	CV1	CV2	CV3	CV4
BMI	1.000
HT	0.072	1.000
CR	−0.025	−0.059	1.000
AGE	−0.065	−0.059	0.086	1.000
WT	0.571	−0.041	−0.070	−0.071	1.000
BSA	0.441	0.923	−0.066	−0.063	0.985	1.000
CRCL	0.476	0.794	−0.368	−0.255	0.916	0.906	1.000
CV1	0.058	−0.078	0.072	−0.010	−0.023	−0.043	−0.050	1.000
CV2	0.134	0.000	0.012	0.041	0.070	0.049	0.057	0.010	1.000
CV3	−0.048	−0.061	0.029	−0.044	−0.073	−0.073	−0.071	0.019	0.000	1.000
CV4	−0.008	−0.030	0.012	0.032	−0.026	−0.032	−0.048	0.024	0.020	−0.026	1.000

BMI body-mass index, HT height, CR creatinine, AGE patient age, WT weight, BSA body-surface area, CRCL creatinine clearance, CV1 first unrelated covariate, CV2 second unrelated covariate, CV3 third unrelated covariate, CV4 fourth unrelated covariate