Table 4.
Haplotype of MBL2 and Disease
| Pathogen, haplotype, infection history | Simple logistic regression |
Multiple logistic regression |
||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Cryptosporidium | ||||
| YO/XA | ||||
| 0 symptomatic infections (n = 159) | 1.00 (reference) | … | 1.00 (reference) | … |
| 1 symptomatic infections (n = 40) | 3.15 (1.37–7.23) | .007 | 3.14 (1.33–7.41) | .009 |
| ≥2 symptomatic infections (n = 16) | 4.42 (1.44–13.5) | .009 | 4.91 (1.49–16.1) | .009 |
| YO/YA | ||||
| 0 symptomatic infections (n = 159) | 1.00 (reference) | … | 1.00 (reference) | … |
| 1 symptomatic infections (n = 40) | 1.54 (0.75–3.16) | .24 | 1.52 (0.72–3.22) | .26 |
| ≥2 symptomatic infections (n = 16) | 0.15 (0.02–1.20) | .07 | 0.15 (0.02–1.19) | .07 |
| E. Histolytica | ||||
| YO/XA | ||||
| 0 symptomatic infections (n = 158) | 1.00 (reference) | … | 1.00 (reference) | … |
| 1 symptomatic infections (n = 35) | 1.05 (0.40–2.78) | .92 | 1.00 (0.37–2.68) | .99 |
| ≥2 symptomatic infections (n = 22) | 1.49 (0.50–4.41) | .47 | 1.40 (0.46–3.27) | .55 |
| YO/YA | ||||
| 0 symptomatic infections (n = 158) | 1.00 (reference) | … | 1.00 (reference) | … |
| 1 symptomatic infections (n = 35) | 0.89 (0.40–1.99) | .78 | 0.81 (0.40–2.04) | .81 |
| ≥2 symptomatic infections (n = 22) | 0.83 (0.31–2.26) | .72 | 0.82 (0.29–2.26) | .70 |
NOTE. The MBL2 haplotype YO/XA demonstrates statistically significant associations with single and multiple Cryptosporidium infections in young children. Other genotypes (YA/YA, YO/YO, YA/XA, and XA/XA) had no statistically significant association with infection. CI, confidence interval; OR, odds ratio.