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. 2012 Jul 19;2:73. doi: 10.3389/fonc.2012.00073

FIGURE 6.

FIGURE 6

Both RAS inhibitors and PPAR agonists prevent radiation-induced cognitive impairment in young adult male rats that received a total 40 Gy dose of fWBI delivered in 5 Gy fractions, twice/week for 4 weeks, and then tested for cognition at 6–12 months post-irradiation using the NOR task. Rats were administered, (A) the ARB, L-158,809 before, during, and for 54 weeks post-fWBI; tested at 52 weeks, (B) the ACEI, ramipril, before, during, and for 28 weeks post-fWBI; tested at 26 weeks, (C) the PPARγ agonist, pioglitazone, before, during, and for 54 weeks post-fWBI; tested at 52 weeks, and (D) the PPARα agonist, fenofibrate, before, during, and for 29 weeks post-fWBI; tested at 26 weeks. *P <0.05, **P <0.01, ***P <0.001 compared to sham-irradiated rats.