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. 2012 Jul 19;3:119. doi: 10.3389/fphar.2012.00119

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Copyright © 2012 Araujo, Zhang and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Heme oxygenase-1 is a critical gene in the activation of endothelial cells by oxPAPC. (A) Visualization of the whole network consisting of 2000 transcripts, organized into 11 modules, shown by distinct colors. Network was constructed based on genomic expression data of HACEs from 149 donors, treated with oxPAPC. Examples of module enrichment in specific pathways are shown. HO-1 is a “hub” of gene-gene interactions in the blue module, enriched in redox and sulfur aminoacid processes. (B) HO-1 mRNA expression. Basal levels varied approximately ninefold at baseline (black curve) but only approximately twofold after treatment with oxPAPC (red circles). (C) Basal HO-1 mRNA levels correlated negatively with IL-6 mRNA expression. Taken from Romanoski et al. (2011).