Figure 1.

Three-dimensional structure models of RVFV Gn and Gc proteins. (A) Schematic representation of the RVFV M-segment polyprotein. Transmembrane and cytoplasmic tail domains are highlighted in dark gray or white bars, respectively. N-Glycosylation sites are indicated with the position of the respective Asn residue. The regions of the two glycoproteins used for molecular modeling are indicated with N and C. 3D molecular models for RVFV (B) Gn and (C) Gc are shown. Secondary structures are highlighted in blue for β-strands, red for α-helices, and gray for turns. The predicted location of the fusion peptide within Gc is represented in purple. The domain nomenclature in modeled Gc were used in adoption to the alphavirus E1 protein. The molecular graphics in this paper were generated with Sculptor (Birmanns et al., 2011) and Chimera (Pettersen et al., 2004).