Table 3.
Strains | Compounds | MIC alone | MIC combined | FICI | MFC alone | MFC combined | FFCI |
---|---|---|---|---|---|---|---|
C. albicans | Cinn | 0.8 | 0.8 | 2.0 | 1.6 | 0.8 | 0.8 |
ATCC 90028 | AMB | 2 | 2 | 4 | 1 | ||
C. albicans | Cinn | 0.8 | 0.8 | 2.0 | 1.6 | 0.8 | 1.0 |
CAN276 | AMB | 2 | 2 | 2 | 1 | ||
C. krusei | Cinn | 0.8 | 0.8 | 2.0 | 1.6 | 0.8 | 1.0 |
ATCC 6258 | AMB | 4 | 4 | 4 (99.8% killing) | 2 | ||
C. krusei | Cinn | 0.8 | 0.8 | 2.0 | 0.8 | 0.8 | 2.0 |
CAN75 | AMB | 4 | 4 | 4 | 4 | ||
C. tropicalis | Cinn | 1.6 | 1.6 | 2.0 | 1.6 | 1.6 | 2.0 |
CAN286 | AMB | 2 | 2 | 4 | 4 | ||
C. neoformans | Cinn | 0.8 | 0.8 | 2.0 | 0.8 | 0.4 | 1.0 |
CN24 | AMB | 4 | 4 | 4 | 2 (99.8% killing) | ||
t-Test | Cinn | P-values: not determined (neutral interaction) | P < 0.1 | ||||
AMB | P < 0.1 |
MFCs are concentrations where ≥99.9% fungal death was achieved, except where noted in the table.
*Cinn, cinnamaldehyde (mM); AMB, amphotericin B (μg mL−1); MIC, minimum inhibitory concentration; MFC, minimum fungicidal concentration; FICI, fractional inhibitory concentration indices; FFCI, fractional fungicidal concentration indices.